U-49900 is primarily studied within controlled laboratory environments for its pharmacological properties as a synthetic opioid. It has become increasingly relevant in fields such as neuropharmacology, toxicology, and forensic chemistry. Researchers explore its receptor-binding potential and compare its effects to better-known analogues like U-47700 to deepen their understanding of novel psychoactive substances (NPS) and synthetic opioid mechanisms.

• Opioid Receptor Affinity Studies
  U-49900 is frequently evaluated for how it interacts with mu-opioid receptors, a key aspect in pain modulation and dependency research. Studies use receptor-binding assays to compare affinity and efficacy against other opioids.

• Structure-Activity Relationship (SAR) Research
  Its close chemical similarity to U-47700 makes U-49900 valuable for SAR analysis. Researchers modify structural components and observe changes in biological activity to understand opioid receptor interactions at a molecular level.

• In Vitro Toxicology Models
  U-49900 is tested on cellular models to evaluate potential toxic effects, including mitochondrial disruption, apoptosis induction, and neurotoxicity markers, without involving live subjects.

• Pharmacokinetic Simulations
  Although human testing is not permitted, simulated models using U-49900 provide insight into how such compounds might be metabolized and distributed in biological systems.

• Comparative Potency Profiling
  By comparing the potency of U-49900 with other synthetic opioids, researchers identify trends in efficacy, onset, and duration that may inform broader NPS categorization.

The legal status of U-49900 varies widely across different countries and jurisdictions, as it is not universally scheduled. While it is often unscheduled and thus legally accessible for research purposes in many regions, researchers must remain vigilant and responsible, ensuring their activities comply with local regulations.

• Not Scheduled in Most Countries
  U-49900 does not currently appear on the controlled substance lists of many countries, making it legally accessible for research in those regions.

• May Fall Under Analogue Laws
  In countries such as the United States or Canada, U-49900 may be considered an analogue of U-47700, which is scheduled. If so, it could be subject to similar legal treatment under analogue or blanket ban provisions.

• Legal for Research Purposes Only
  Even where it’s not controlled, U-49900 is only legal when used for legitimate scientific research. Any use outside of research (such as human consumption) could constitute a criminal offense.

• RC Plug Advises Checking Local Laws
  We strongly encourage every buyer to verify the legal status of U-49900 in their specific region before placing an order to avoid customs issues or legal consequences.

• Customs and Import Risks May Vary
  Some countries impose discretionary restrictions during customs inspections, even for unscheduled substances. Understanding import documentation requirements is crucial.

In its most common form, U-49900 is a white to off-white crystalline powder. This form is standard for synthetic opioids and research chemicals, as it facilitates accurate weighing, consistent dosing in assays, and easy dissolution for in vitro work.

• Physical Appearance
  U-49900 is typically a fine crystalline powder, free from visible contaminants. It has a uniform particle size that ensures stability in measurement and solution preparation.

• Color Characteristics
  The color is usually off-white, although it may range slightly depending on the exact purification process. A consistent color can indicate batch purity.

• Texture and Consistency
  Its texture is dry, free-flowing, and non-clumpy — optimal for lab handling. Clumps may suggest moisture contamination and should be avoided.

• Odorless Composition
  High-purity U-49900 is odorless, a sign that volatile impurities have been effectively removed during synthesis and purification.

• Solubility Factors
  While physical form is dry, it is moderately soluble in ethanol and DMSO, which is relevant for certain in vitro research techniques.

U-49900 is structurally similar to U-47700 but is considered to be slightly less potent in terms of its interaction with opioid receptors. Despite this, it remains a significant compound for research due to its unique binding characteristics, which allow researchers to observe nuanced differences in receptor response and efficacy.

• Reduced Mu-Receptor Affinity
  Comparative in vitro tests show U-49900 has a lower binding affinity to mu-opioid receptors than U-47700, suggesting reduced potency in terms of receptor activation.

• Longer Onset Curve
  Simulated response models indicate U-49900 may exhibit a longer onset period, allowing for more controlled study windows and response measurements.

• Lower Overdose Risk in Controlled Studies
  Due to its reduced potency, U-49900 may pose a lower toxicity threshold in laboratory simulations, offering a safer model for in vitro toxicology research.

• Structurally Instructive
  Its similar structure, combined with reduced potency, makes U-49900 ideal for studying structural modifications’ effect on receptor binding.

• Not Suitable for In Vivo Use
  Regardless of potency, U-49900 is not approved for in vivo or human testing due to its potential toxicity and lack of pharmacological safety data.

Handling U-49900 in a laboratory setting requires strict safety protocols due to its classification as a synthetic opioid and its potential bioactivity. Researchers must adhere to best practices in chemical hygiene, lab safety, and documentation to mitigate all possible risks.

• Use of Personal Protective Equipment (PPE)
  Lab personnel should always wear gloves, safety goggles, and lab coats. In some cases, full-body PPE is recommended when handling larger quantities.

• Work Within a Fume Hood
  Manipulating U-49900 inside a fume hood prevents airborne particles from being inhaled and ensures environmental containment in case of spills.

• Dedicated Lab Tools
  Equipment used to weigh or mix U-49900 should not be shared with other chemicals to prevent cross-contamination and ensure accurate results.

• Proper Labeling and Storage
  All containers must be clearly labeled with the substance name, hazard warnings, and concentration details. Containers should be stored in locked cabinets.

• Disposal According to Hazardous Waste Protocols
  U-49900 waste must be handled through proper chemical disposal services, as standard trash disposal poses safety and legal risks.

• Avoid Skin and Mucous Membrane Contact
  Direct exposure to the skin or inhalation may result in unintended effects, even at low doses, due to its opioid nature.

Storing U-49900 properly is essential to maintain its chemical stability, purity, and integrity over time. Because it is a moisture- and light-sensitive compound, appropriate storage prevents degradation, ensures consistent research results, and extends its shelf life. Laboratories must apply strict storage protocols, especially when handling compounds with opioid receptor activity.

• Keep in a Cool, Dry Place
  U-49900 should be stored at room temperature or slightly below, ideally between 15–25°C. Avoiding high temperatures helps prevent chemical breakdown and potency loss.

• Use Airtight Containers
  Exposure to air can lead to oxidation and contamination. Researchers should always store U-49900 in sealed, airtight vials or amber glass containers.

• Protect From Light
  UV light can degrade the molecular structure of synthetic opioids. Store the compound in opaque or amber-colored containers, and keep them in a dark environment or cabinet.

• Avoid Humidity and Moisture
  U-49900 is hygroscopic and may clump or degrade when exposed to moisture. Silica gel packets can be placed inside storage containers to absorb residual humidity.

• Refrigeration Not Always Required
  While some compounds require cold storage, U-49900 remains stable at room temperature if kept in ideal conditions. Refrigeration is optional but beneficial for long-term storage.

• Label Clearly and Securely
  Containers must be labeled with the compound name, concentration, date of receipt, and expiration period to prevent mishandling or misuse.

• Limit Frequent Handling
  Repeated exposure to open air each time the container is accessed can degrade the product. Use smaller aliquots for day-to-day research tasks.

As of now, U-49900 does not have an officially assigned CAS (Chemical Abstracts Service) number, which is common among newer or less-commercialized research chemicals. Despite the lack of a CAS number, U-49900 is still traceable through its molecular structure, IUPAC name, and chemical formula for academic and scientific use.

• Unregistered by CAS
  U-49900 is not listed in the CAS registry, making it a non-standard compound in terms of chemical cataloging and regulatory classification.

• Identified by IUPAC Name
  The IUPAC designation — 3,4-dichloro-N-[2-(dimethylamino)cyclohexyl]-N-methylbenzamide — is internationally recognized and used in research documentation.

• Cataloged Internally by Suppliers
  Research chemical suppliers like RC Plug assign internal batch IDs and lot numbers to ensure traceability, even in the absence of a CAS code.

• Molecular Formula and Structure for Validation
  U-49900’s structure (C16H22Cl2N2O) allows for definitive identification using analytical techniques such as NMR, HPLC, and MS.

• Important for Regulatory Compliance
  While the absence of a CAS number limits mainstream chemical registration, researchers must still adhere to local chemical safety and storage guidelines.

• Cross-Referencing in Lab Reports
  When recording research involving U-49900, scientists typically cite the IUPAC name or internal lab reference code to ensure reproducibility.

U-49900’s molecular structure is central to its classification as a synthetic opioid. It features a substituted benzamide core, modified with dichloro groups and a dimethylamino-cyclohexyl side chain. This configuration contributes to its affinity for opioid receptors and places it among U-series compounds in structure-activity research.

• Benzamide Backbone
  The foundation of U-49900 is a benzamide group, a common pharmacophore in synthetic opioids, which facilitates receptor binding.

• Dichloro Substitution
  The 3,4-dichloro groups on the aromatic ring enhance receptor affinity and influence electron distribution, which affects bioactivity.

• Cyclohexylamine Segment
  Attached to the amide is a cyclohexyl ring, which introduces spatial bulk and impacts the compound’s pharmacokinetic properties.

• Dimethylamino Functional Group
  This polar group contributes to water solubility and interaction with biological targets, playing a role in compound metabolism.

• Molecular Formula: C16H22Cl2N2O
  This reflects its atomic composition: 16 carbon, 22 hydrogen, 2 chlorine, 2 nitrogen, and 1 oxygen atom.

• Molecular Weight: 329.26 g/mol
  Used for accurate measurement in lab scales, this weight influences solution preparation and dosing precision in studies.

• Structural Similarity to U-47700
  U-49900 differs only slightly from U-47700, making it valuable in analog comparison research aimed at identifying structural impact on potency.

Shipping U-49900 to the United States or countries in the European Union is possible under certain conditions, especially when intended solely for research purposes. However, import restrictions, analogue laws, and customs discretion must be taken into account when planning shipments to these regions.

• U.S. Federal Law
  U-49900 is not scheduled under the Controlled Substances Act at the federal level, making it potentially legal for research purposes. However, certain states may have analogue or blanket bans that apply.

• European Union Regulations Vary by Country
  Some EU nations allow the importation of U-49900 for research use, while others may treat it as a controlled analogue. It is essential to check national chemical control laws before ordering.

• Customs Discretion Applies
  Customs officials may detain or return packages if the compound is suspected to violate import policies, regardless of its unscheduled status.

• RC Plug Provides Guidance
  We assist customers by offering accurate product descriptions, documentation support, and discreet packaging to minimize customs-related issues.

• Scientific Import Use
  Shipments are handled as research chemical consignments, not consumer goods. Proper labeling and scientific intent declarations improve clearance success.

• Tracking and Delivery Assurance
  All orders shipped to the US or EU include a real-time tracking number and are packaged to comply with international shipping standards for laboratory materials.

Contamination of U-49900, like with any research chemical, can compromise the validity of laboratory results and pose safety hazards. Cross-contamination, degradation, and adulteration are risks that researchers must mitigate by following best practices in handling, sourcing, and storage.

• Inaccurate Research Data
  Impure or contaminated samples can distort test results, especially in receptor binding or in vitro response assays, leading to unreliable conclusions.

• Increased Toxicity Risks
  Contaminants can introduce unknown toxic effects, particularly if degradation products form reactive intermediates under lab conditions.

• Compromised Chemical Stability
  Exposure to moisture, light, or air can degrade U-49900, resulting in loss of potency and altered chemical behavior.

• Interference in Analytical Equipment
  Contaminated samples may leave residues in HPLC columns or NMR tubes, which can affect other experiments and compromise lab equipment.

• Quality Assurance from RC Plug
  Every batch of U-49900 from RC Plug is independently lab-tested for purity (≥98%) and screened for contaminants using GC-MS and NMR analysis.

• Safe Packaging and Handling
  To prevent contamination during transit or storage, our products are sealed in tamper-evident, moisture-proof containers.

At RC Plug, we understand how critical consistency and reliability are for research, which is why we’ve established a hassle-free return and replacement policy. If your U-49900 order arrives damaged, compromised, or doesn’t meet the product description, we stand behind our 30-day refund or replacement policy to ensure your research isn’t disrupted.

• 30-Day Full Refund or Replacement Guarantee
  If your U-49900 shipment is damaged or lost in transit, you are entitled to a complete refund or free reshipment, no questions asked, within 30 days of delivery.

• Applies to Packaging Issues or Product Defects
  Whether it’s external damage to the parcel, compromised seals, or material discrepancies in product quality, our support team is ready to resolve it promptly.

• Photo Documentation May Be Requested
  To validate the issue and improve future packaging, we may ask for clear images of the damaged product or shipping materials.

• Fast Dispute Resolution
  Claims are handled quickly, typically within 1–3 business days, ensuring you don’t face unnecessary research delays.

• No Restocking Fees or Hidden Costs
  We cover the full cost of the replacement or refund without administrative deductions — what you paid is what you get back.

• Customer-Centered Process
  Our focus is on maintaining your trust. If there’s ever any issue, we make it right immediately with no resistance or bureaucracy.

U-49900 holds a unique position in synthetic opioid research due to its structural closeness to U-47700, yet lower potency and distinctive pharmacological profile. These traits make it a useful model for studying opioid receptor interactions, toxicological profiles, and the SAR (structure-activity relationship) among emerging NPS compounds.

• Analogue of U-47700
  U-49900 retains the benzamide scaffold of U-47700 but differs in potency and receptor affinity, offering valuable contrast for receptor activity mapping.

• Less Regulated Than Similar Opioids
  Because U-49900 is often unscheduled, it provides researchers in certain jurisdictions with a legal option for conducting opioid-related experiments.

• Ideal for SAR and Receptor Modeling
  Its structure allows for fine-grained research on how minor molecular changes influence mu-opioid receptor binding and downstream effects.

• Used in Forensic and Toxicological Profiling
  U-49900 is increasingly used in forensic toxicology labs to simulate and understand the metabolism and risk profile of emerging opioids.

• Stability and Ease of Handling
  Compared to some analogues, U-49900 has a longer shelf life and more manageable storage requirements, enhancing its value in controlled research environments.

• Benchmark Compound in Novel Opioid Libraries
  U-49900 is often included in broader studies aiming to develop databases of emerging opioids, serving as a reference point for comparison.

Yes, U-49900 is soluble in several organic solvents, which is important for its use in laboratory preparations such as chromatography, spectroscopy, and assay setups. Understanding its solubility profile helps researchers choose the appropriate medium for in vitro applications and chemical analysis.

• Soluble in Ethanol
  U-49900 readily dissolves in ethanol, making it suitable for many lab protocols involving spectrophotometric or bioassay preparations.

• Soluble in DMSO (Dimethyl Sulfoxide)
  DMSO is another highly effective solvent for U-49900, frequently used in cellular assays due to its biological compatibility and solvent strength.

• Limited Solubility in Water
  As a hydrophobic compound, U-49900 does not dissolve well in water, which limits its use in aqueous-based studies unless solubilizing agents are added.

• Pre-Dilution Recommended for Dosing Accuracy
  To ensure consistent application in experiments, U-49900 is often pre-diluted into stock solutions and then measured out in microliter quantities.

• Solubility May Vary by Purity and Batch
  While general solubility properties hold, slight variations in particle size or residual solvents may affect solubility across batches — making test runs essential.

• Use of Sonication Can Improve Dissolution
  In cases of partial solubility, applying ultrasonic agitation (sonication) can help fully dissolve the compound in a solvent.

Yes, although U-49900 is not fully cataloged in pharmaceutical databases, preliminary laboratory data and anecdotal reports suggest it has a defined melting point range. Determining the melting point is essential for confirming purity and structural consistency during compound verification.

• Estimated Melting Point Range: 210–220°C
  Based on thermal analysis in lab environments, U-49900 exhibits a melting point in this range, aligning with expectations for compounds of its class.

• Used to Assess Purity
  A narrow melting point range often indicates a highly pure compound. Broader or inconsistent ranges may suggest contamination or structural degradation.

• Supports Batch Quality Control
  Measuring melting point is a common secondary method in quality assurance processes, confirming the identity of U-49900 batches alongside spectroscopic techniques.

• Not Widely Published
  As an unregistered compound, melting point data for U-49900 is generally available only through proprietary lab testing or private documentation.

• Thermal Decomposition Risks at Higher Temps
  Heating U-49900 above its melting point can cause decomposition, possibly producing hazardous byproducts, hence the need for controlled handling.

Yes, all U-49900 orders from RC Plug include a secure, real-time tracking number as part of our standard shipping protocol. We believe in full transparency from checkout to delivery, and our tracking system is designed to keep you informed every step of the way.

• Tracking Code Provided Within 24 Hours of Shipping
  Once your payment is confirmed and the order is dispatched, a tracking number is generated and sent via email or SMS.

• Real-Time Carrier Updates
  You’ll receive location updates directly from our courier partners, allowing you to monitor each stage of your shipment’s journey.

• Anonymous Tracking Descriptions
  To maintain discretion, tracking labels do not reference the contents or indicate the nature of the item, protecting your privacy.

• Works Across International Borders
  Our tracking system functions globally, so you can monitor your order whether you’re in the U.S., EU, Asia, or elsewhere.

• Customer Support Available for Issues
  If your tracking info appears delayed or unresponsive, our support team will contact the carrier and provide status updates within 24 hours.

• Expected Delivery Timeframes Included
  Tracking notifications include estimated delivery windows, and in most cases, U-49900 arrives within 2–7 business days depending on your region.

At RC Plug, we prioritize secure and anonymous payment options that align with the privacy and needs of the research community. To minimize transaction friction and increase accessibility worldwide, we support a variety of trusted alternative payment platforms — but do not currently accept credit card payments due to compliance and risk considerations.

• Bitcoin (BTC)
  We accept Bitcoin for its speed, low fees, and strong privacy features. It is often the preferred payment option for international researchers due to its decentralized nature.

• Zelle
  Zelle is widely used in the United States and offers fast, direct bank-to-bank transfers. It’s ideal for domestic orders with same-day confirmation.

• Bank Transfer
  Traditional wire transfers are accepted and commonly used by institutions. Bank details are provided upon checkout and confirmation usually occurs within 1–2 business days.

• CashApp
  Popular in North America, CashApp allows users to send funds quickly using mobile numbers or usernames, making it convenient for independent researchers.

• Western Union
  For countries where online payments are restricted, Western Union remains a reliable option. It supports both physical and online money transfers.

• Why Credit Cards Are Not Accepted
  Due to banking restrictions and chargeback risks associated with research chemical transactions, we do not accept credit cards at this time. This policy ensures uninterrupted service and risk mitigation.