Semax is a synthetic peptide developed from a fragment of the adrenocorticotropic hormone (ACTH), specifically the ACTH(4-10) analog. Originally created by Russian scientists, Semax is primarily researched for its neuroprotective, nootropic, and cognitive-enhancing properties. It has been widely studied in Eastern Europe for clinical applications and is considered a promising candidate in neuropharmacology and brain injury research.

• Synthetic ACTH Fragment:
  Semax is derived from the ACTH(4–10) peptide sequence, Met-Glu-His-Phe-Pro-Gly-Pro, which has been chemically modified to enhance its neurological activity and duration of action while eliminating hormonal effects.

• Nootropic and Cognitive Potential:
  It is widely researched for its ability to improve memory, focus, and attention—especially under conditions of fatigue, hypoxia, or chronic stress—by modulating neurotrophic factor expression.

• Neuroprotective Properties:
  Studies show that Semax may help protect neurons from oxidative stress and ischemic damage, making it a strong candidate for research into stroke and traumatic brain injury recovery.

• Regulatory Status:
  Though approved for clinical use in Russia and Ukraine, Semax remains an investigational research chemical in most countries and is not FDA-approved for human use.

• Research Applications:
  It is commonly used in experimental models focusing on cognitive enhancement, depression, neurodegeneration, ADHD, and brain ischemia.

• Administration Route:
  Most research focuses on intranasal delivery due to its non-invasive nature and ability to rapidly cross the blood-brain barrier.

Researchers utilize Semax in both academic and private-sector studies due to its unique ability to enhance cognitive performance, regulate neurochemistry, and protect neural tissues from damage. Its multifunctional profile makes it highly valuable in neuroscience, psychopharmacology, and brain regeneration studies.

• Boosts Brain-Derived Neurotrophic Factor (BDNF):
  Semax has been shown to significantly increase BDNF levels, which supports neurogenesis, learning, and long-term memory formation in experimental models.

• Enhances Attention and Working Memory:
  Research indicates improvements in executive functioning, sustained attention, and short-term memory, particularly under mentally fatiguing or stressful conditions.

• Accelerates Post-Stroke Recovery:
  In animal and limited human studies, Semax demonstrated potential to reduce neurological deficits and aid recovery in ischemic brain injury scenarios.

• Anti-Anxiety and Antidepressant Effects:
  Semax is being studied for its mood-regulating properties, showing possible modulation of dopamine and serotonin systems, which are vital in mental health research.

• Protects Against Neurotoxicity:
  It may shield neurons from the harmful effects of oxidative stress and excitotoxicity by regulating antioxidant enzyme activity and inflammatory responses.

• Minimal Hormonal Effects:
  Unlike natural ACTH, Semax does not influence cortisol levels, making it ideal for research where hormonal interference is a concern.

At RC Plug, we offer Semax in two high-purity, research-ready forms tailored to the different needs of scientific investigations: lyophilized powder and ready-to-use intranasal spray. Each form is produced to the highest laboratory standards with full documentation and analysis.

• Lyophilized Powder Vials:
  Our freeze-dried Semax peptide is available in sterile glass vials with quantities ranging from 5 mg to 50 mg. This format is ideal for researchers who require control over reconstitution volumes and administration routes.

• Intranasal Spray Kits:
  Pre-formulated Semax nasal sprays (e.g., 30 mg per bottle) offer convenient and accurate dosing for experiments requiring non-invasive central nervous system delivery.

• Tamper-Proof Packaging:
  All forms are shipped in vacuum-sealed, moisture-resistant foil pouches to maintain stability and prevent degradation during shipping.

• Research Grade Purity:
  Both powder and spray forms are ≥ 99% pure, HPLC-tested, and come with a Certificate of Analysis and batch-specific documentation.

• Flexible Quantities for Small or Large Labs:
  Whether you’re running pilot studies or full-scale trials, we offer scalable volume options and bulk pricing upon request.

Proper reconstitution of lyophilized Semax is essential for maintaining peptide integrity and ensuring reproducibility in experimental settings. This step must be conducted under sterile lab conditions using suitable solvents like bacteriostatic water.

• Use Bacteriostatic Water (Preferred):
  For safety and longevity, bacteriostatic water is the most suitable solvent, as it contains 0.9% benzyl alcohol, which inhibits bacterial growth.

• Volume Determination:
  The volume of water used depends on the intended final concentration. For example, to achieve a 1 mg/mL solution, dissolve 10 mg Semax in 10 mL of bacteriostatic water.

• Aseptic Techniques Required:
  Always reconstitute peptides in a sterile lab environment using alcohol-wiped surfaces, gloves, and cleanroom tools to prevent contamination.

• Swirl, Don’t Shake:
  Mix gently by swirling the vial. Avoid vigorous shaking, as peptides are delicate and can degrade with mechanical stress.

• Refrigerate After Mixing:
  Once reconstituted, store the solution at 2–8 °C. It remains stable for up to 6 weeks under proper refrigeration.

• Label Clearly:
  Document the date of reconstitution and concentration on the vial for accurate tracking and compliance with lab protocols.

The CAS number for Semax is 80714-61-0. This unique numerical identifier is used globally to specify chemical substances in databases, regulatory filings, scientific publications, and procurement systems. It provides an unambiguous reference for researchers, ensuring consistent recognition of the compound across platforms.

• Globally Recognized Identifier:
  CAS numbers are maintained by the American Chemical Society and are the industry standard for identifying chemicals with precision and consistency.

• Used in Lab Inventory & Procurement:
  Researchers use the CAS number to ensure they’re ordering the exact compound needed for their studies, especially when naming conventions vary across suppliers.

• Helpful in Literature Searches:
  Searching databases like PubChem or SciFinder by CAS number ensures that results specifically relate to Semax and not to similar peptides.

• Included in Our Documentation:
  Every batch of Semax from RC Plug includes the CAS number on its Certificate of Analysis (COA), shipping documents, and vial labels for regulatory and archival purposes.

• Required for Customs Declarations (in Some Countries):
  For customs processing in certain jurisdictions, the CAS number may be referenced to comply with import regulations related to research chemicals.

Proper storage is essential to maintain Semax’s chemical integrity, especially since peptides are highly sensitive to temperature, moisture, and oxidation. Adhering to best storage practices ensures long-term stability and consistent research performance.

• Unopened Lyophilized Powder:
  Store the sealed vial at or below –20 °C in a freezer. This keeps the peptide stable for up to 24–36 months.

• After Reconstitution:
  Once reconstituted with bacteriostatic water, Semax should be refrigerated at 2–8 °C and used within 4–6 weeks for optimal potency.

• Minimize Freeze-Thaw Cycles:
  Avoid repeatedly freezing and thawing the vial. If necessary, divide reconstituted solution into aliquots for single-use storage.

• Protect from Light:
  Store in amber vials or wrap in foil to protect from light degradation, which can destabilize peptide bonds over time.

• Seal Tightly:
  Ensure the vial is tightly sealed to prevent moisture and air exposure, which could lead to hydrolysis or oxidation.

• Label Reconstitution Date:
  Always mark the vial with the reconstitution date and storage temperature to maintain accurate lab records and follow protocols.

At RC Plug, we offer Semax in flexible dosage formats designed to accommodate a wide range of research applications and study models. These formats are particularly suited to neuropharmacological, behavioral, and biochemical research.

• 5 mg Vial:
  Suitable for small pilot studies or microdosing protocols. Allows researchers to fine-tune reconstitution volume for ultra-precise dosing.

• 10 mg Vial:
  A popular mid-range option ideal for short-term experiments and initial testing phases.

• 25 mg & 50 mg Vials:
  Designed for more extensive or ongoing studies. These larger quantities reduce the need for frequent reordering and allow consistent dosing across trials.

• 30 mg Intranasal Spray Kits:
  Preloaded nasal sprays provide researchers with a non-invasive administration route and consistent delivery volume per spray.

• Custom Bulk Orders:
  Upon request, we offer bulk production or packaging suited for institutional or high-volume use, with full customization of concentration and vial size.

• All Dosage Forms COA-Verified:
  Each dosage form is tested and delivered with a Certificate of Analysis confirming purity, concentration, and batch validation.

No. At RC Plug, Semax is sold strictly for laboratory research and in vitro use only. It is not approved for human or veterinary use by the FDA or any other regulatory agency outside its limited clinical use in Russia and certain Eastern European countries.

• Research-Only Classification:
  Semax is intended solely for use in preclinical studies, in vitro cellular assays, or animal models under professional lab conditions.

• Not FDA-Approved:
  In the United States and most other countries, Semax is not approved as a drug or supplement. It must not be administered to humans under any circumstances outside of a regulated clinical trial.

• Labeling and Shipping Compliance:
  All our shipments are clearly labeled “Not for Human Consumption” and include safety data in accordance with chemical safety and transportation regulations.

• Institutional Use Only:
  Our products are intended for qualified researchers, academic labs, or companies with proper protocols and ethical oversight.

• No Dosage Instructions for Humans:
  We do not provide or support any guidance on personal use, medical dosing, or off-label application. Any such practice is strictly prohibited.

Research suggests that Semax begins to take effect within 15 to 60 minutes after administration, particularly via intranasal delivery. The onset of its neurochemical actions is fast due to its direct passage through the olfactory bulb into the central nervous system, bypassing the blood-brain barrier.

• Intranasal Absorption Speed:
  The peptide is rapidly absorbed through the nasal mucosa into the brain, allowing for fast pharmacodynamic action in cognitive and behavioral studies.

• Peak Concentration Timeline:
  Preclinical models indicate that measurable neurochemical changes such as BDNF upregulation can begin as early as 1–2 hours post-administration.

• Sustained Effects:
  Depending on the dosage and study model, effects may persist for several hours, making it suitable for acute and sub-acute research timelines.

• Study-Dependent Variables:
  Onset timing may vary depending on dosage, route of administration, species studied, and endpoints measured (e.g., memory, motor coordination, enzyme activity).

• Cognitive Performance Models:
  Some studies show improved attention and learning performance within 60 minutes in stress-induced or fatigue-loaded experimental conditions.

• Neuroprotective Timelines:
  In ischemic or trauma models, early administration of Semax has been associated with reduced damage markers within 24 hours.

Semax is a multifaceted peptide that supports a wide range of research applications within neuroscience, pharmacology, and experimental therapeutics. Its mechanism of action makes it suitable for investigating both cognitive enhancement and neuroprotective pathways under various physiological and pathological conditions.

• Cognitive Enhancement Research:
  Semax has been widely studied for its ability to improve learning, memory, attention, and mental clarity in models of cognitive fatigue, aging, or high-stress environments.

• Neurodegenerative Disease Studies:
  It is used in experimental models of Alzheimer’s disease, Parkinson’s disease, and other neurodegenerative conditions to observe neurotrophin expression and protection against neural decay.

• Ischemic Brain Injury Models:
  Researchers use Semax to assess how it may mitigate damage from stroke, hypoxia, or other oxygen-deprivation states, due to its anti-inflammatory and antioxidant properties.

• ADHD and Behavioral Neuroscience:
  Due to its influence on dopamine and serotonin pathways, Semax is used in animal studies simulating attention deficit disorders and behavioral anomalies.

• Post-Traumatic Brain Injury (TBI) Studies:
  Semax shows potential in improving functional recovery and neural regeneration post-TBI, making it a candidate for trauma-based research.

• Mood and Depression Models:
  Some studies focus on its modulation of neurochemical markers linked to anxiety and depression, especially under chronic stress or serotonin-depleted conditions.

• Anti-Inflammatory & Immune Modulation:
  Semax may reduce pro-inflammatory cytokine expression and regulate the immune response, which adds value to studies involving autoimmune neuroinflammation or neuroimmune regulation.

Semax works through multiple biological pathways, giving it a broad and robust pharmacological profile. While its complete mechanism is still being explored, it has been found to regulate neurotrophic factors, influence receptor signaling, and enhance brain antioxidant defenses.

• BDNF and NGF Upregulation:
  One of Semax’s key actions is the enhancement of brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF), both essential for neuroplasticity, learning, and cell survival.

• TrkB Receptor Activation:
  By increasing BDNF, Semax indirectly activates TrkB receptors, initiating downstream signaling pathways like MAPK/ERK and PI3K/Akt—crucial for cell growth and repair.

• Enkephalinase Inhibition:
  Semax has been shown to inhibit enkephalin-degrading enzymes, which helps maintain elevated levels of endogenous opioids, reducing pain perception and anxiety in some models.

• Melanocortin Receptor Modulation:
  As an ACTH analog, Semax binds to melanocortin receptors (particularly MC4R and MC5R), involved in energy regulation, stress response, and immune modulation.

• Antioxidant Enzyme Stimulation:
  In models of oxidative stress, Semax enhances the activity of antioxidant enzymes like superoxide dismutase (SOD) and glutathione peroxidase (GPx), protecting against cellular damage.

• Synaptic Transmission Modulation:
  It influences synaptic efficiency by regulating the availability of neurotransmitters such as dopamine, acetylcholine, and serotonin, contributing to its cognitive and mood effects.

• Anti-inflammatory Cytokine Suppression:
  Semax reduces levels of inflammatory cytokines like IL-6 and TNF-α in ischemic and trauma conditions, contributing to its neuroprotective action.

While Semax is generally considered well-tolerated in animal models and clinical settings in Russia, it remains a research compound. Any side effects observed are typically mild and transient, but they are essential to document in controlled environments.

• Mild Blood Pressure Fluctuations:
  Some studies report minor, temporary changes in blood pressure due to its modulation of melanocortin receptors. These effects are typically self-limiting.

• Headache or Dizziness (Rare):
  In limited human observations, mild headaches or dizziness were reported, often associated with higher dosages or prolonged use.

• Nasal Irritation (Intranasal Use):
  When administered intranasally, a few subjects in trials experienced mild nasal irritation or dryness, especially with frequent application.

• Mood Shifts or Anxiety (Uncommon):
  Due to its neuromodulatory effects, some research indicates possible fluctuations in mood, especially during dose escalation studies.

• No Hormonal Side Effects:
  Despite being an ACTH analog, Semax does not increase cortisol levels or interfere with adrenal gland function, reducing risk of hormonal imbalance.

• Not Suitable for Human Use Outside Research:
  Because it has not undergone full toxicological profiling in all jurisdictions, any human-side effect data must be considered preliminary and not conclusive.

• Unknown Long-Term Safety Profile:
  Longitudinal studies are lacking in non-Russian publications, so the long-term implications of regular exposure are still under investigation.

Semax occupies a legal gray area in many countries, and its regulatory status varies significantly by jurisdiction. In most regions, it is not classified as a controlled substance but is also not authorized for human consumption or commercial medical use.

• Not a Scheduled Substance:
  In the U.S., U.K., Canada, and most EU countries, Semax is not listed as a controlled drug or narcotic, allowing for lawful research use under proper protocols.

• Prescription-Only in Some Countries:
  In Russia and Ukraine, Semax is approved for clinical use as a prescription medication to treat ischemic stroke, cognitive dysfunction, and optic nerve diseases.

• Sold for Research Use Only:
  At RC Plug, we clearly state that our Semax is sold exclusively for laboratory and scientific research, not for self-experimentation or clinical applications.

• Shipping Compliance:
  We provide all necessary labeling and documentation to ensure customs compliance. However, researchers are responsible for ensuring Semax is permitted in their country.

• Not FDA-Approved:
  In the United States, Semax is not approved by the Food and Drug Administration for therapeutic or dietary use and is not listed in the U.S. Pharmacopoeia.

• Subject to Institutional Oversight:
  Universities and laboratories often require institutional approval and ethical board oversight for using Semax in animal or in vitro studies.

Yes, we include a Certificate of Analysis (COA) with every Semax order. The COA is a critical document in the research community, offering proof of quality, purity, and chemical identity of the peptide you’re working with.

• Batch-Specific Information:
  Each COA is tied to the specific lot of Semax you’ve purchased, listing the batch number, synthesis date, and expiration.

• Purity and Identity Confirmation:
  The COA outlines results from HPLC and mass spectrometry testing, confirming ≥ 99% purity and accurate molecular weight.

• Physical and Chemical Data:
  Information such as solubility, storage recommendations, appearance (white lyophilized powder), and molecular structure are detailed on the COA.

• Contaminant Testing:
  It includes microbiological assessments and residual solvent analysis to ensure no harmful levels of endotoxins, heavy metals, or solvents are present.

• Authentication and Traceability:
  Our COAs are generated from our internal QC lab or trusted third-party facilities and signed by a qualified QA officer to ensure traceability.

• Available in Digital and Physical Format:
  A digital copy of the COA is available at purchase, and a printed version is included in your shipment for lab documentation purposes.

At RC Plug, we back every order with a 30-day full refund or replacement policy. This is our commitment to customer satisfaction, ensuring that you can order with full confidence in the quality and service we provide.

• 30-Day Satisfaction Guarantee:
  If your order arrives damaged, incorrect, or compromised in any way, you can request a full refund or replacement within 30 days of receipt.

• Eligible Conditions for Refund:
  We offer refunds for issues including shipment loss, wrong item delivered, product contamination, or broken vials upon arrival.

• Easy Return Process:
  Contact our support team with your order ID, photos (if applicable), and a brief description of the issue. We will promptly initiate the resolution process.

• No Refund for Opened Research Use Products (Unless Faulty):
  Due to the nature of research chemicals, we generally do not refund opened products unless there’s a confirmed quality issue based on documentation.

• Full Replacement Option:
  If preferred, we can send a replacement product immediately without waiting for the return, especially when research timelines are critical.

• No Restocking Fees:
  We do not charge restocking fees for returns—our policy is transparent, fair, and research-friendly.

• Supportive Customer Service:
  Our support agents are available 24/7 via email and secure chat to assist with refund or replacement requests.